Response to tocilizumab and work productivity in patients with rheumatoid arthritis: 2-year follow-up of FIRST ACT-SC study.
Identifieur interne : 000191 ( 2020/Analysis ); précédent : 000190; suivant : 000192Response to tocilizumab and work productivity in patients with rheumatoid arthritis: 2-year follow-up of FIRST ACT-SC study.
Auteurs : Yoshiya Tanaka [Japon] ; Hideto Kameda [Japon] ; Kazuyoshi Saito [Japon] ; Yuko Kaneko [Japon] ; Eiichi Tanaka [Japon] ; Shinsuke Yasuda [Japon] ; Naoto Tamura [Japon] ; Keishi Fujio [Japon] ; Takao Fujii [Japon] ; Toshihisa Kojima [Japon] ; Tatsuhiko Anzai [Japon] ; Chikuma Hamada [Japon] ; Yoshihisa Fujino [Japon] ; Shinya Matsuda [Japon] ; Hitoshi Kohsaka [Japon]Source :
- Modern rheumatology [ 1439-7609 ] ; 2020.
Abstract
Objectives: We evaluated long-term control of rheumatoid arthritis (RA) in Japanese paid workers (PWs) and house workers (HWs) treated with subcutaneous tocilizumab (TCZ-SC) and explored factors affecting response to TCZ-SC regarding work productivity.Methods: This study collected data from patients with RA in the TCZ-SC +/- conventional synthetic disease-modifying antirheumatic drugs group. Factors affecting the response to tocilizumab regarding work productivity were explored using logistic regression. Differences in quality-adjusted life years (QALYs) between with/without response were analysed by a linear regression.Results: Data were analysed for 357/360 patients. Patients with a ≥ 75% improvement in activity impairment (AI) were considered responders. EuroQol-5 Dimension (EQ-5D), six-item Kessler psychological distress scale score (K6), Health Assessment Questionnaire Disability Index (HAQ-DI), and the patient's disease global health by visual analogue scale were significant contributors to TCZ-SC response based on improvements in AI. Work Functioning Impairment Scale, presenteeism, EQ-5D, K6, and HAQ-DI significantly contributed to the improvement of overall work impairment in PWs. Shorter disease duration also was related to TCZ-SC response based on AI improvements. Responders had significantly larger mean QALYs than non-responders (difference = 0.2614; p < .001).Conclusions: These real-world clinical data support long-term work productivity control with TCZ-SC for biologic-naïve HWs and PWs with RA.
DOI: 10.1080/14397595.2019.1709681
PubMed: 31903822
Affiliations:
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pubmed:31903822Le document en format XML
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Medical University, Wakayama, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Rheumatology and Clinical Immunology, Wakayama Medical University, Wakayama</wicri:regionArea><wicri:noRegion>Wakayama</wicri:noRegion></affiliation></author><author><name sortKey="Kojima, Toshihisa" sort="Kojima, Toshihisa" uniqKey="Kojima T" first="Toshihisa" last="Kojima">Toshihisa Kojima</name><affiliation wicri:level="1"><nlm:affiliation>Department of Orthopaedics/Rheumatology, Nagoya University Graduate School of Medicine, Aichi, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Orthopaedics/Rheumatology, Nagoya University Graduate School of Medicine, Aichi</wicri:regionArea><wicri:noRegion>Aichi</wicri:noRegion></affiliation></author><author><name sortKey="Anzai, Tatsuhiko" sort="Anzai, Tatsuhiko" uniqKey="Anzai T" first="Tatsuhiko" last="Anzai">Tatsuhiko Anzai</name><affiliation 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Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>The First Department of Internal Medicine, University of Occupational and Environmental Health Japan, Fukuoka</wicri:regionArea><wicri:noRegion>Fukuoka</wicri:noRegion></affiliation></author><author><name sortKey="Kameda, Hideto" sort="Kameda, Hideto" uniqKey="Kameda H" first="Hideto" last="Kameda">Hideto Kameda</name><affiliation wicri:level="3"><nlm:affiliation>Toho University, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Toho University, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Saito, Kazuyoshi" sort="Saito, Kazuyoshi" uniqKey="Saito K" first="Kazuyoshi" last="Saito">Kazuyoshi Saito</name><affiliation wicri:level="1"><nlm:affiliation>The First Department of Internal Medicine, University of Occupational and Environmental Health Japan, Fukuoka, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>The First Department of Internal Medicine, University of Occupational and Environmental Health Japan, Fukuoka</wicri:regionArea><wicri:noRegion>Fukuoka</wicri:noRegion></affiliation></author><author><name sortKey="Kaneko, Yuko" sort="Kaneko, Yuko" uniqKey="Kaneko Y" first="Yuko" last="Kaneko">Yuko Kaneko</name><affiliation wicri:level="3"><nlm:affiliation>Division of Rheumatology Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Rheumatology Department of Internal Medicine, Keio University School of Medicine, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Tanaka, Eiichi" sort="Tanaka, Eiichi" uniqKey="Tanaka E" first="Eiichi" last="Tanaka">Eiichi Tanaka</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Rheumatology, Tokyo Women's Medical University Hospital, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Institute of Rheumatology, Tokyo Women's Medical University Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Yasuda, Shinsuke" sort="Yasuda, Shinsuke" uniqKey="Yasuda S" first="Shinsuke" last="Yasuda">Shinsuke Yasuda</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Endocrinology, and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Hokkaido, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Rheumatology, Endocrinology, and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Hokkaido</wicri:regionArea><wicri:noRegion>Hokkaido</wicri:noRegion></affiliation></author><author><name sortKey="Tamura, Naoto" sort="Tamura, Naoto" uniqKey="Tamura N" first="Naoto" last="Tamura">Naoto Tamura</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine and Rheumatology, Juntedo University School of Medicine, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Internal Medicine and Rheumatology, Juntedo University School of Medicine, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Fujio, Keishi" sort="Fujio, Keishi" uniqKey="Fujio K" first="Keishi" last="Fujio">Keishi Fujio</name><affiliation wicri:level="4"><nlm:affiliation>Department of Allergy and Rheumatology, The University of Tokyo, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Allergy and Rheumatology, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName></affiliation></author><author><name sortKey="Fujii, Takao" sort="Fujii, Takao" uniqKey="Fujii T" first="Takao" last="Fujii">Takao Fujii</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Clinical Immunology, Wakayama Medical University, Wakayama, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Rheumatology and Clinical Immunology, Wakayama Medical University, Wakayama</wicri:regionArea><wicri:noRegion>Wakayama</wicri:noRegion></affiliation></author><author><name sortKey="Kojima, Toshihisa" sort="Kojima, Toshihisa" uniqKey="Kojima T" first="Toshihisa" last="Kojima">Toshihisa Kojima</name><affiliation wicri:level="1"><nlm:affiliation>Department of Orthopaedics/Rheumatology, Nagoya University Graduate School of Medicine, Aichi, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Orthopaedics/Rheumatology, Nagoya University Graduate School of Medicine, Aichi</wicri:regionArea><wicri:noRegion>Aichi</wicri:noRegion></affiliation></author><author><name sortKey="Anzai, Tatsuhiko" sort="Anzai, Tatsuhiko" uniqKey="Anzai T" first="Tatsuhiko" last="Anzai">Tatsuhiko Anzai</name><affiliation wicri:level="3"><nlm:affiliation>EPS Corporation, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>EPS Corporation, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Hamada, Chikuma" sort="Hamada, Chikuma" uniqKey="Hamada C" first="Chikuma" last="Hamada">Chikuma Hamada</name><affiliation wicri:level="3"><nlm:affiliation>Tokyo University of Science, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo University of Science, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Fujino, Yoshihisa" sort="Fujino, Yoshihisa" uniqKey="Fujino Y" first="Yoshihisa" last="Fujino">Yoshihisa Fujino</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health, University of Occupational and Environmental Health Japan, Fukuoka, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Public Health, University of Occupational and Environmental Health Japan, Fukuoka</wicri:regionArea><wicri:noRegion>Fukuoka</wicri:noRegion></affiliation></author><author><name sortKey="Matsuda, Shinya" sort="Matsuda, Shinya" uniqKey="Matsuda S" first="Shinya" last="Matsuda">Shinya Matsuda</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health, University of Occupational and Environmental Health Japan, Fukuoka, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Public Health, University of Occupational and Environmental Health Japan, Fukuoka</wicri:regionArea><wicri:noRegion>Fukuoka</wicri:noRegion></affiliation></author><author><name sortKey="Kohsaka, Hitoshi" sort="Kohsaka, Hitoshi" uniqKey="Kohsaka H" first="Hitoshi" last="Kohsaka">Hitoshi Kohsaka</name><affiliation wicri:level="3"><nlm:affiliation>Department of Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Rheumatology, Tokyo Medical and Dental University, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author></analytic><series><title level="j">Modern rheumatology</title><idno type="eISSN">1439-7609</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><b>Objectives:</b> We evaluated long-term control of rheumatoid arthritis (RA) in Japanese paid workers (PWs) and house workers (HWs) treated with subcutaneous tocilizumab (TCZ-SC) and explored factors affecting response to TCZ-SC regarding work productivity.<b>Methods:</b> This study collected data from patients with RA in the TCZ-SC +/- conventional synthetic disease-modifying antirheumatic drugs group. Factors affecting the response to tocilizumab regarding work productivity were explored using logistic regression. Differences in quality-adjusted life years (QALYs) between with/without response were analysed by a linear regression.<b>Results:</b> Data were analysed for 357/360 patients. Patients with a ≥ 75% improvement in activity impairment (AI) were considered responders. EuroQol-5 Dimension (EQ-5D), six-item Kessler psychological distress scale score (K6), Health Assessment Questionnaire Disability Index (HAQ-DI), and the patient's disease global health by visual analogue scale were significant contributors to TCZ-SC response based on improvements in AI. Work Functioning Impairment Scale, presenteeism, EQ-5D, K6, and HAQ-DI significantly contributed to the improvement of overall work impairment in PWs. Shorter disease duration also was related to TCZ-SC response based on AI improvements. Responders had significantly larger mean QALYs than non-responders (difference = 0.2614; <i>p</i> < .001).<b>Conclusions:</b> These real-world clinical data support long-term work productivity control with TCZ-SC for biologic-naïve HWs and PWs with RA.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement><orgName><li>Université de Tokyo</li></orgName></list><tree><country name="Japon"><noRegion><name sortKey="Tanaka, Yoshiya" sort="Tanaka, Yoshiya" uniqKey="Tanaka Y" first="Yoshiya" last="Tanaka">Yoshiya Tanaka</name></noRegion><name sortKey="Anzai, Tatsuhiko" sort="Anzai, Tatsuhiko" uniqKey="Anzai T" first="Tatsuhiko" last="Anzai">Tatsuhiko Anzai</name><name sortKey="Fujii, Takao" sort="Fujii, Takao" uniqKey="Fujii T" first="Takao" last="Fujii">Takao Fujii</name><name sortKey="Fujino, Yoshihisa" sort="Fujino, Yoshihisa" uniqKey="Fujino Y" first="Yoshihisa" last="Fujino">Yoshihisa Fujino</name><name sortKey="Fujio, Keishi" sort="Fujio, Keishi" uniqKey="Fujio K" first="Keishi" last="Fujio">Keishi Fujio</name><name sortKey="Hamada, Chikuma" sort="Hamada, Chikuma" uniqKey="Hamada C" first="Chikuma" last="Hamada">Chikuma Hamada</name><name sortKey="Kameda, Hideto" sort="Kameda, Hideto" uniqKey="Kameda H" first="Hideto" last="Kameda">Hideto Kameda</name><name sortKey="Kaneko, Yuko" sort="Kaneko, Yuko" uniqKey="Kaneko Y" first="Yuko" last="Kaneko">Yuko Kaneko</name><name sortKey="Kohsaka, Hitoshi" sort="Kohsaka, Hitoshi" uniqKey="Kohsaka H" first="Hitoshi" last="Kohsaka">Hitoshi Kohsaka</name><name sortKey="Kojima, Toshihisa" sort="Kojima, Toshihisa" uniqKey="Kojima T" first="Toshihisa" last="Kojima">Toshihisa Kojima</name><name sortKey="Matsuda, Shinya" sort="Matsuda, Shinya" uniqKey="Matsuda S" first="Shinya" last="Matsuda">Shinya Matsuda</name><name sortKey="Saito, Kazuyoshi" sort="Saito, Kazuyoshi" uniqKey="Saito K" first="Kazuyoshi" last="Saito">Kazuyoshi Saito</name><name sortKey="Tamura, Naoto" sort="Tamura, Naoto" uniqKey="Tamura N" first="Naoto" last="Tamura">Naoto Tamura</name><name sortKey="Tanaka, Eiichi" sort="Tanaka, Eiichi" uniqKey="Tanaka E" first="Eiichi" last="Tanaka">Eiichi Tanaka</name><name sortKey="Yasuda, Shinsuke" sort="Yasuda, Shinsuke" uniqKey="Yasuda S" first="Shinsuke" last="Yasuda">Shinsuke Yasuda</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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